| Title : Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors - Andreani_2008_Eur.J.Med.Chem_43_657 |
| Author(s) : Andreani A , Burnelli S , Granaiola M , Guardigli M , Leoni A , Locatelli A , Morigi R , Rambaldi M , Rizzoli M , Varoli L , Roda A |
| Ref : Eur Journal of Medicinal Chemistry , 43 :657 , 2008 |
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Abstract :
The synthesis of a new series of imidazo[2,1-b]thiazole derivatives is described. They were tested as potential acetylcholinesterase and butyrylcholinesterase inhibitors by means of a chemiluminescent microassay. Although most of the new compounds did not show significant cholinesterase inhibition potency, three of them displayed selective antiacetylcholinesterase activity in the micromolar range. |
| PubMedSearch : Andreani_2008_Eur.J.Med.Chem_43_657 |
| PubMedID: 17624631 |
Andreani A, Burnelli S, Granaiola M, Guardigli M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Rizzoli M, Varoli L, Roda A (2008)
Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors
Eur Journal of Medicinal Chemistry
43 :657
Andreani A, Burnelli S, Granaiola M, Guardigli M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Rizzoli M, Varoli L, Roda A (2008)
Eur Journal of Medicinal Chemistry
43 :657