Annapurna_1991_Diabetologia_34_320

This study was designed to understand the reasons for the increase in serum pseudocholinesterase activity in diabetes mellitus Streptozotocin-induced diabetic rats were used for the study Serum pseudocholinesterase activity increased with the induction of diabetes 381.5 units/l 11.8 compared to the non-diabetic rats 243.1 units/l 7.2 Serum triglycerides total low density lipoprotein and glycerol also increased concurrently with the development of diabetes Insulin treatment of the diabetic rats normalized serum glucose concomitant with the reduction of pseudocholinesterase activity triglycerides total low density lipoprotein and glycerol Heparin injection appeared to activate lipoprotein lipase in the diabetic rats by showing a marked fall in serum triglyceride and total low density lipoprotein levels but not in pseudocholinesterase activity Administration of tetraisopropylpyrophosphoramide a specific pseudocholinesterase inhibitor inhibited serum and adipose tissue pseudocholinesterase activity by greater than 80 and liver greater than 50 Concurrent with the inhibition of pseudocholinesterase activity serum triglyceride low density lipoprotein and glycerol decreased significantly In normal rats treatment with tetraisopropylpyrophosphoramide also reduced serum lipoproteins markedly while glycerol only showed a marginal decrease Glycerol was used as a marker of adipose tissue lipolysis and total low density lipoprotein which is defined as lipoproteins of density less than 1.063 LDL VLDL).