Antunovic_2013_Int.Urol.Nephrol_45_1111

PURPOSE: We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients.
METHODS: SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method.
RESULTS: sUA among survivors (112.1 +/- 13.82 mumol/L) was significantly lower than in deceased (160.8 +/- 16.81 mumol/L, p < 0.001), while SOD was higher in survivors (31.8 +/- 6.61 kU/L) than among deceased (20.2 +/- 3.03, p < 0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (>/=127.11 mumol/L, p < 0.001), and for SOD in the lowest tertile (<=23.83 kU/L, p < 0.05). CONCLUSION: Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.