| Title : Lembehyne a, a spongean polyacetylene, induces neuronal differentiation in neuroblastoma cell - Aoki_2001_Biochem.Biophys.Res.Commun_289_558 |
| Author(s) : Aoki S , Matsui K , Takata T , Hong W , Kobayashi M |
| Ref : Biochemical & Biophysical Research Communications , 289 :558 , 2001 |
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Abstract :
Lembehyne A (LB-A), a spongean polyacetylene, induced neuronal cell differentiation in a neuroblastoma cell line, Neuro 2A. The LB-A treatment of Neuro 2A cells predominantly resulted in a morphological change with bipolar neurites. The acetylcholinesterase activity of Neuro 2A was also increased by the treatment of LB-A. Furthermore, the cell cycle of Neuro 2A cells was found to be specifically blocked at the G1 phase by LB-A. The structure-activity relationship study using the LB-A analogues revealed the importance of the terminal 1-yn-3-ol and unsaturated long-chain alkyl moieties for the neuronal differentiation activity of LB-A. |
| PubMedSearch : Aoki_2001_Biochem.Biophys.Res.Commun_289_558 |
| PubMedID: 11716510 |
Aoki S, Matsui K, Takata T, Hong W, Kobayashi M (2001)
Lembehyne a, a spongean polyacetylene, induces neuronal differentiation in neuroblastoma cell
Biochemical & Biophysical Research Communications
289 :558
Aoki S, Matsui K, Takata T, Hong W, Kobayashi M (2001)
Biochemical & Biophysical Research Communications
289 :558