| Title : Pyridoacridine Alkaloids Inducing Neuronal Differentiation in a Neuroblastoma Cell Line, from Marine Sponge Biemna fortis - Aoki_2003_Bioorg.Med.Chem_11_1969 |
| Author(s) : Aoki S , Wei H , Matsui K , Rachmat R , Kobayashi M |
| Ref : Bioorganic & Medicinal Chemistry , 11 :1969 , 2003 |
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Abstract :
A new and three known pyridoacridine alkaloids were isolated from the Indonesian marine sponge Biemna fortis as neuronal differentiation inducers against a murine neuroblastoma cell line, Neuro 2A. The chemical structure of the new compound, labuanine A (1), was determined by spectroscopic study and chemical conversion. These pyridoacridine alkaloids induced multipolar neuritogenesis in more than 50% of cells at 0.03-3 micro M concentration. Compound 3, which showed the strongest neuritogenic activity among them, also induced increase of acetylcholinesterase, a neuronal marker in Neuro 2A and arrested cell cycle at the G2/M phase. |
| PubMedSearch : Aoki_2003_Bioorg.Med.Chem_11_1969 |
| PubMedID: 12670647 |
Aoki S, Wei H, Matsui K, Rachmat R, Kobayashi M (2003)
Pyridoacridine Alkaloids Inducing Neuronal Differentiation in a Neuroblastoma Cell Line, from Marine Sponge Biemna fortis
Bioorganic & Medicinal Chemistry
11 :1969
Aoki S, Wei H, Matsui K, Rachmat R, Kobayashi M (2003)
Bioorganic & Medicinal Chemistry
11 :1969