| Title : Effect of denervation on acetylcholine synthesizing activity and nicotine-like binding sites in rat hind limb muscles - Aquilonius_1982_Acta.Physiol.Scand_114_345 |
| Author(s) : Aquilonius SM , Askmark H , Eckernas SA , Nordberg A |
| Ref : Acta Physiologica Scandinavica , 114 :345 , 1982 |
|
Abstract :
The acetylcholine synthesizing (ACh-s) activity and the binding of the nicotine ligands 3H-alpha-bungarotoxin (alpha Btx) and 3H-d-tubocurarine (d-TC) were analysed in rat hind limb muscles 1-32 days after denervation. Muscles of the contralateral leg served as controls. ACh-s activity was considerably lower in tibialis anterior as compared to the extensor digitorum longus and the peroneus longus muscles. After denervation there was a rapid decrease in ACh-s activity in parallel to a considerable increase in alpha-Btx binding. The binding of d-TC was essentially unchanged following denervation indicating the special characteristics of the newly formed receptors. ACh-s activity can be differentiated into one specific (choline acetyltransferase) and one unspecific component. |
| PubMedSearch : Aquilonius_1982_Acta.Physiol.Scand_114_345 |
| PubMedID: 7136765 |
Aquilonius SM, Askmark H, Eckernas SA, Nordberg A (1982)
Effect of denervation on acetylcholine synthesizing activity and nicotine-like binding sites in rat hind limb muscles
Acta Physiologica Scandinavica
114 :345
Aquilonius SM, Askmark H, Eckernas SA, Nordberg A (1982)
Acta Physiologica Scandinavica
114 :345