| Title : Synthesis and Evaluation of Chroman-4-One Linked to N-Benzyl Pyridinium Derivatives as New Acetylcholinesterase Inhibitors - Arab_2015_Arch.Pharm.(Weinheim)_348_643 |
| Author(s) : Arab S , Sadat-Ebrahimi SE , Mohammadi-Khanaposhtani M , Moradi A , Nadri H , Mahdavi M , Moghimi S , Asadi M , Firoozpour L , Pirali-Hamedani M , Shafiee A , Foroumadi A |
| Ref : Arch Pharm (Weinheim) , 348 :643 , 2015 |
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Abstract :
A novel series of chroman-4-one derivatives containing the N-benzyl pyridinium moiety were designed, synthesized, and evaluated for their acetylcholinesterase (AChE) inhibitory activities. Among the various synthesized compounds, (E)-1-(2,3-dibromobenzyl)-4-((7-ethoxy-4-oxochroman-3-ylidene)methyl)pyridinium bromide (8l) depicted the most potent anti-AChE activity (IC50 = 0.048 muM). In addition, the molecular modeling study allowed us to detect possible binding modes that are in full compliance with the observed results through in vitro experiments. |
| PubMedSearch : Arab_2015_Arch.Pharm.(Weinheim)_348_643 |
| PubMedID: 26192069 |
Arab S, Sadat-Ebrahimi SE, Mohammadi-Khanaposhtani M, Moradi A, Nadri H, Mahdavi M, Moghimi S, Asadi M, Firoozpour L, Pirali-Hamedani M, Shafiee A, Foroumadi A (2015)
Synthesis and Evaluation of Chroman-4-One Linked to N-Benzyl Pyridinium Derivatives as New Acetylcholinesterase Inhibitors
Arch Pharm (Weinheim)
348 :643
Arab S, Sadat-Ebrahimi SE, Mohammadi-Khanaposhtani M, Moradi A, Nadri H, Mahdavi M, Moghimi S, Asadi M, Firoozpour L, Pirali-Hamedani M, Shafiee A, Foroumadi A (2015)
Arch Pharm (Weinheim)
348 :643