Armengaud_2001_Neurosci.Lett_304_97

The objective of this study was to determine if nicotinic receptor antagonists known for their ability to impair memory in the honeybee could induce changes in brain metabolism. We tested the effect of antagonists [hexamethonium, mecamylamine, alpha-bungarotoxin (alpha-BTX)] and agonist (nicotine) brain injections on cytochrome oxidase (CO) histochemistry. Within as little as 30 min following nicotine injection, an increase of the staining was observed in almost all the structures analyzed. The increase was limited to the alpha-lobe after alpha-BTX injection. In contrast, the antagonists hexamethonium and mecamylamine reduced CO staining in this structure that seems to be involved in information retrieval. These results suggest that the decrease of metabolism in the alpha-lobe obtained with hexamethonium and mecamylamine injections could be related to the impairment of retrieval processes previously observed with these drugs.