| Title : Hydrogen-bond accepting strength of protonated nicotine - Arnaud_2005_J.Phys.Chem.A_109_3767 |
| Author(s) : Arnaud V , Berthelot M , Le Questel JY |
| Ref : J Phys Chem A , 109 :3767 , 2005 |
|
Abstract :
Recent crystal structures of nicotine bound to the acetylcholine binding protein (AChBP) ended a long debate confirming that the pyridine nitrogen of nicotine is indeed hydrogen-bonded to receptor residues through a bridging water molecule. Here, we describe the first direct experimental evaluation of the hydrogen-bond affinity of the nicotinium pyridine nitrogen. The equilibrium constant of its association with a phenol is 1 order of magnitude greater than the association of the acetylcholine carbonyl oxygen. |
| PubMedSearch : Arnaud_2005_J.Phys.Chem.A_109_3767 |
| PubMedID: 16833690 |
Arnaud V, Berthelot M, Le Questel JY (2005)
Hydrogen-bond accepting strength of protonated nicotine
J Phys Chem A
109 :3767
Arnaud V, Berthelot M, Le Questel JY (2005)
J Phys Chem A
109 :3767