Arora_1993_Biochem_31_413

The effect of insulin induced hypoglycemia was studied on the activities of Acetylcholinesterase (AChE) which hydrolizes acetylcholine (ACh) and Na+, K(+)-ATPase, the enzymatic version of Na+,K(+)-pump from rat heart, liver and kidney. AChE activity was decreased significantly from two subcellular fractions of all the three tissues after 1,2 and 3 hours of insulin administration (5 units/100 gm body weight) Na+, K(+)-ATPase activity was decreased in liver and kidney, whereas, a significant increase in heart ATPase activity was observed. Blood glucose level was significantly lower than control values after 1, 2 and 3 hours of insulin injection, and the protein content from these tissues did not show any significant change under this physiological stress.