Arsito_2023_Heliyon_9_e21894

Reference

Title : Multifunctional effect of flavonoids from Millettia brandisiana against Alzheimer's disease pathogenesis - Arsito_2023_Heliyon_9_e21894
Author(s) : Arsito PN , Waiwut P , Yenjai C , Arthan S , Monthakantirat O , Nualkaew N , Takomthong P , Boonyarat C
Ref : Heliyon , 9 :e21894 , 2023
Abstract :

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment and neuronal death. Fifteen flavonoids from Millettia brandisiana were evaluated for the multifunctional effect against AD pathogenesis, including butyrylcholine esterase (BuChE) inhibition, anti-amyloid beta (Abeta) aggregation and neuroprotection against hydrogen peroxide (H(2)O(2)) toxicity in differentiated human neuroblastoma SH-SY5Y cell. To understand the mechanism and structure-activity relationship, binding interactions between flavonoids and the BuChE and Abeta were investigated in silico. Furthermore, drug-likeness properties and ADMET parameters were evaluated in silico using SwissADME and pKCSM tools. All flavonoids exhibit a good drug-likeness profile. Six flavonoids have potency in BuChE inhibition, and four flavonoids show potency in anti-Abeta aggregation. Flavonoids with the 6'',6''-dimethylchromeno- [2'',3'':7,8]-flavone structure show a favorable multifunctional effect. In silico analysis showed that flavonoids can bind in various positions to the catalytic triad, anionic site, and acyl pocket. In Abeta(1-42), potential flavonoids can attach to the central hydrophobic region and the C terminal hydrophobic and interfere with Abeta interchain hydrogen binding. When compared together, it can inhibit multifunctional action with a favorable ADMET parameter and drug-likeness profile. In addition, candidine can prevent neuronal damage in differentiated SH-SY5Y neuroblastoma cells induced by H(2)O(2) in a dose-dependent manner.

PubMedSearch : Arsito_2023_Heliyon_9_e21894
PubMedID: 38106662

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Citations formats

Arsito PN, Waiwut P, Yenjai C, Arthan S, Monthakantirat O, Nualkaew N, Takomthong P, Boonyarat C (2023)
Multifunctional effect of flavonoids from Millettia brandisiana against Alzheimer's disease pathogenesis
Heliyon 9 :e21894

Arsito PN, Waiwut P, Yenjai C, Arthan S, Monthakantirat O, Nualkaew N, Takomthong P, Boonyarat C (2023)
Heliyon 9 :e21894