| Title : Triazole substituted metal-free, metallo-phthalocyanines and their water soluble derivatives as potential cholinesterases inhibitors: Design, synthesis and in vitro inhibition study - Arslan_2019_Bioorg.Chem_90_103100 |
| Author(s) : Arslan T , Cakir N , Keles T , Biyiklioglu Z , Senturk M |
| Ref : Bioorg Chem , 90 :103100 , 2019 |
|
Abstract :
In this study, 1,2,3-triazole substituted metal-free and metallo phthalocyanines (4, 5, 6) and their water soluble derivatives (4a, 5a, 6a) were designed, synthesized for the first time and tested in vitro on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Most phthalocyanines exhibited good inhibitory activities on these enzymes. Among the six phthalocyanines and starting compounds, 4a showed the most interesting profile as a submicromolar selective inhibitor of AChE (IC50=0.040microM) and 5a showed the most effective inhibitor of BChE (IC50=0.1198microM). |
| PubMedSearch : Arslan_2019_Bioorg.Chem_90_103100 |
| PubMedID: 31288136 |
Arslan T, Cakir N, Keles T, Biyiklioglu Z, Senturk M (2019)
Triazole substituted metal-free, metallo-phthalocyanines and their water soluble derivatives as potential cholinesterases inhibitors: Design, synthesis and in vitro inhibition study
Bioorg Chem
90 :103100
Arslan T, Cakir N, Keles T, Biyiklioglu Z, Senturk M (2019)
Bioorg Chem
90 :103100