| Title : Achiral bis-imine in combination with CoCl(2): A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol - Arunkumar_2010_Beilstein.J.Org.Chem_6_1174 |
| Author(s) : Arunkumar K , Reddy MA , Kumar TS , Kumar BV , Chandrasekhar KB , Kumar PR , Pal M |
| Ref : Beilstein J Org Chem , 6 :1174 , 2010 |
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Abstract :
A bis-imine (prepared via a new FeCl(3)-based method) in combination with CoCl(2) facilitated lipase-mediated acetylation of the (R)-isomer of a racemic benzylic secondary alcohol with 91% ee(s). The methodology was used for the preparation of the known drug rivastigmine. |
| PubMedSearch : Arunkumar_2010_Beilstein.J.Org.Chem_6_1174 |
| PubMedID: 21160565 |
Arunkumar K, Reddy MA, Kumar TS, Kumar BV, Chandrasekhar KB, Kumar PR, Pal M (2010)
Achiral bis-imine in combination with CoCl(2): A remarkable effect on enantioselectivity of lipase-mediated acetylation of racemic secondary alcohol
Beilstein J Org Chem
6 :1174
Arunkumar K, Reddy MA, Kumar TS, Kumar BV, Chandrasekhar KB, Kumar PR, Pal M (2010)
Beilstein J Org Chem
6 :1174