| Title : An insight into the sialome of the blood-sucking bug Triatoma infestans, a vector of Chagas' disease - Assumpcao_2008_Insect.Biochem.Mol.Biol_38_213 |
| Author(s) : Assumpcao TC , Francischetti IM , Andersen JF , Schwarz A , Santana JM , Ribeiro JM |
| Ref : Insect Biochemistry & Molecular Biology , 38 :213 , 2008 |
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Abstract :
Triatoma infestans is a hemiptera, vector of Chagas' disease that feeds exclusively on vertebrate blood in all life stages. Hematophagous insects' salivary glands (SG) produce potent pharmacological compounds that counteract host hemostasis, including anticlotting, antiplatelet, and vasodilatory molecules. To obtain a further insight into the salivary biochemical and pharmacological complexity of this insect, a cDNA library from its SG was randomly sequenced. Also, salivary proteins were submitted to two-dimensional gel (2D-gel) electrophoresis followed by MS analysis. We present the analysis of a set of 1534 (SG) cDNA sequences, 645 of which coded for proteins of a putative secretory nature. Most salivary proteins described as lipocalins matched peptide sequences obtained from proteomic results. |
| PubMedSearch : Assumpcao_2008_Insect.Biochem.Mol.Biol_38_213 |
| PubMedID: 18207082 |
Assumpcao TC, Francischetti IM, Andersen JF, Schwarz A, Santana JM, Ribeiro JM (2008)
An insight into the sialome of the blood-sucking bug Triatoma infestans, a vector of Chagas' disease
Insect Biochemistry & Molecular Biology
38 :213
Assumpcao TC, Francischetti IM, Andersen JF, Schwarz A, Santana JM, Ribeiro JM (2008)
Insect Biochemistry & Molecular Biology
38 :213