| Title : Lipase-catalyzed preparation of S-propranolol in presence of hydroxypropyl beta-cyclodextrins - Avila-Gonzalez_2005_J.Biosci.Bioeng_100_423 |
| Author(s) : Avila-Gonzalez R , Perez-Gilabert M , Garcia-Carmona F |
| Ref : J Biosci Bioeng , 100 :423 , 2005 |
|
Abstract :
A simple method for the preparation of S-propranolol catalyzed by a Rhizopus niveus lipase in an aqueous medium is described. Hydroxypropyl-beta-cyclodextrin was used for the first time to increase the solubility of (R,S)-O-butyryl propranolol thus permitting the reaction to be carried out in water. The formation of an inclusion complex between (R,S)-O-butyryl propranolol and hydroxypropyl-beta-cyclodextrin was studied and a stoichiometry of 1:1 was determined. The influences of the hydroxypropyl-beta-cyclodextrin concentration, pH and percentage of ethanol on the enzymatic activity were also investigated. Under the conditions presented in this paper, values of ee(s) of 90% and E=48 were obtained. |
| PubMedSearch : Avila-Gonzalez_2005_J.Biosci.Bioeng_100_423 |
| PubMedID: 16310732 |
Avila-Gonzalez R, Perez-Gilabert M, Garcia-Carmona F (2005)
Lipase-catalyzed preparation of S-propranolol in presence of hydroxypropyl beta-cyclodextrins
J Biosci Bioeng
100 :423
Avila-Gonzalez R, Perez-Gilabert M, Garcia-Carmona F (2005)
J Biosci Bioeng
100 :423