Bacigalupo_2001_Bone.Marrow.Transplant_28_1041

Serum cholinesterase CHE has been reported to be a significant indicator of liver function and prognosis in patients with cirrhosis On the other hand liver complications are frequent following allogeneic stem cell transplantation HSCT We therefore tested whether CHE was predictive of graft-versus-host disease and outcome in HSCT recipients We studied 689 patients receiving a HSCT from an HLA-identical sibling SIB n 511 an alternative donor n 173 or a syngeneic twin n 5 Acute graft-versus-host disease GVHD was scored as 0-I II III-IV in 325 47 279 41 and 85 patients 12 respectively 190 28 patients died of transplant-related complications TRM On day 7 the median CHE serum level was comparable in patients who either survived or died of TRM 5900 IU/l On day