| Title : Sulfonamides as multifunctional agents for Alzheimer's disease - Bag_2015_Bioorg.Med.Chem.Lett_25_626 |
| Author(s) : Bag S , Tulsan R , Sood A , Cho H , Redjeb H , Zhou W , LeVine H, 3rd , Torok B , Torok M |
| Ref : Bioorganic & Medicinal Chemistry Lett , 25 :626 , 2015 |
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Abstract :
Sulfonamide linker-based inhibitors with extended linear structure were designed and synthesized with the aim of producing multifunctional agents against several processes involved in the pathology of Alzheimer's disease (AD). The potency of the compounds were assessed in the inhibition of Abeta self-assembly (fibril and oligomer formation), in modulating cholinesterase (AChE, BCHE) activity, and scavenging free radicals. Several compounds exhibited promising Abeta self-assembly and cholinesterase inhibition and in parallel, showed good free radical scavenging properties. The investigation of the scaffold described in this study resulted in the identification of three compounds (14, 19 and 26) as promising leads for the further design of multifunctional drug candidates for AD. |
| PubMedSearch : Bag_2015_Bioorg.Med.Chem.Lett_25_626 |
| PubMedID: 25537270 |
Bag S, Tulsan R, Sood A, Cho H, Redjeb H, Zhou W, LeVine H, 3rd, Torok B, Torok M (2015)
Sulfonamides as multifunctional agents for Alzheimer's disease
Bioorganic & Medicinal Chemistry Lett
25 :626
Bag S, Tulsan R, Sood A, Cho H, Redjeb H, Zhou W, LeVine H, 3rd, Torok B, Torok M (2015)
Bioorganic & Medicinal Chemistry Lett
25 :626