Bajgar_2012_Mil.Med.Sci.Lett_81_164

OBJECTIVES: The aim of this study is to inform about different techniques used to improve treatment of nerve agents intoxication at the Department of Toxicology.METHODS: Different methods are briefly mentioned and their importance for development of more effective reactivators is discussed. RESULTS: Basic characterization of nerve agents and therapeutic drugs is necessary after literature survey. Usage of different techniques and properties of various reactivators are studied and, on this basis, the most effective ones are tested in details and proposed for practical use. CONCLUSIONS: The results described in this study clearly demonstrate that for the development of new and more effective cholinesterase reactivators a complex approach using different methodical attitudes is necessary.