| Title : Toxicological assessment of 3-chloropropane-1,2-diol and glycidol fatty acid esters in food - Bakhiya_2011_Mol.Nutr.Food.Res_55_509 |
| Author(s) : Bakhiya N , Abraham K , Gurtler R , Appel KE , Lampen A |
| Ref : Mol Nutr Food Res , 55 :509 , 2011 |
| Abstract : Fatty acid esters of 3-chloropropane-1,2-diol (3-MCPD) and glycidol are a newly identified class of food process contaminants. They are widespread in refined vegetable oils and fats and have been detected in vegetable fat-containing products, including infant formulas. There are no toxicological data available yet on the 3-MCPD and glycidol esters, and the primary toxicological concern is based on the potential release of 3-MCPD or glycidol from the parent esters by lipase-catalyzed hydrolysis in the gastrointestinal tract. Although 3-MCPD is assessed as a nongenotoxic carcinogen with a tolerable daily intake (TDI) of 2 microg/kg body weight (bw), glycidol is a known genotoxic carcinogen, which induces tumors in numerous organs of rodents. The initial exposure estimates, conducted by Federal Institute for Risk Assessment (BfR) under the assumption that 100% of the 3-MPCD and glycidol are released from their esters, revealed especially that infants being fed commercial infant formula could ingest harmful amounts of 3-MCPD and glycidol. However, the real oral bioavailability may be lower. As this gives rise for toxicological concern, the currently available toxicological data of 3-MCPD and glycidol and their esters are summarized in this review and discussed with regard to data gaps and further research needs. |
| ESTHER : Bakhiya_2011_Mol.Nutr.Food.Res_55_509 |
| PubMedSearch : Bakhiya_2011_Mol.Nutr.Food.Res_55_509 |
| PubMedID: 21351250 |
Bakhiya N, Abraham K, Gurtler R, Appel KE, Lampen A (2011)
Toxicological assessment of 3-chloropropane-1,2-diol and glycidol fatty acid esters in food
Mol Nutr Food Res
55 :509
Bakhiya N, Abraham K, Gurtler R, Appel KE, Lampen A (2011)
Mol Nutr Food Res
55 :509