| Title : A facile route to paclitaxel C-10 carbamates - Ballatore_2005_Bioorg.Med.Chem.Lett_15_2477 |
| Author(s) : Ballatore C , Aspland SE , Castillo R , Desharnais J , Eustaquio T , Sun C , Castellino AJ , Smith AB, 3rd |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2477 , 2005 |
|
Abstract :
A general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2'-O-TBS-7-O-TES-10-O-deacetyl-paclitaxel-10-O-carbonylimidazole prior to reaction with amines. This method is effective for the synthesis of paclitaxel C-10 derivatives, including bifunctional molecules. |
| PubMedSearch : Ballatore_2005_Bioorg.Med.Chem.Lett_15_2477 |
| PubMedID: 15863300 |
Ballatore C, Aspland SE, Castillo R, Desharnais J, Eustaquio T, Sun C, Castellino AJ, Smith AB, 3rd (2005)
A facile route to paclitaxel C-10 carbamates
Bioorganic & Medicinal Chemistry Lett
15 :2477
Ballatore C, Aspland SE, Castillo R, Desharnais J, Eustaquio T, Sun C, Castellino AJ, Smith AB, 3rd (2005)
Bioorganic & Medicinal Chemistry Lett
15 :2477