Barillet_2011_Environ.Pollut_159_495

Reference

Title : Uranium bioaccumulation and biological disorders induced in zebrafish (Danio rerio) after a depleted uranium waterborne exposure - Barillet_2011_Environ.Pollut_159_495
Author(s) : Barillet S , Adam-Guillermin C , Palluel O , Porcher JM , Devaux A
Ref : Environ Pollut , 159 :495 , 2011
Abstract :

Because of its toxicity and its ubiquity within aquatic compartments, uranium (U) represents a significant hazard to aquatic species such as fish. In a previous study, we investigated some biological responses in zebrafish either exposed to depleted or to enriched U (i.e., to different radiological activities). However, results required further experiments to better understand biological responses. Moreover, we failed to clearly demonstrate a significant relationship between biological effects and U radiological activity. We therefore chose to herein examine U bioaccumulation and induced effects in zebrafish according to a chemical dose-response approach. Results showed that U is highly bioconcentrated in fish, according to a time- and concentration-dependent model. Additionally, hepatic antioxidant defenses, red blood cells DNA integrity and brain acetylcholinesterase activity were found to be significantly altered. Generally, the higher the U concentration, the sooner and/or the greater the effect, suggesting a close relationship between accumulation and effect.

PubMedSearch : Barillet_2011_Environ.Pollut_159_495
PubMedID: 21093136

Related information

Citations formats

Barillet S, Adam-Guillermin C, Palluel O, Porcher JM, Devaux A (2011)
Uranium bioaccumulation and biological disorders induced in zebrafish (Danio rerio) after a depleted uranium waterborne exposure
Environ Pollut 159 :495

Barillet S, Adam-Guillermin C, Palluel O, Porcher JM, Devaux A (2011)
Environ Pollut 159 :495