| Title : Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506) - Barreiro_2012_J.Bacteriol_194_3756 |
| Author(s) : Barreiro C , Prieto C , Sola-Landa A , Solera E , Martinez-Castro M , Perez-Redondo R , Garcia-Estrada C , Aparicio JF , Fernandez-Martinez LT , Santos-Aberturas J , Salehi-Najafabadi Z , Rodriguez-Garcia A , Tauch A , Martin JF |
| Ref : Journal of Bacteriology , 194 :3756 , 2012 |
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Abstract :
The macrocyclic polyketide tacrolimus (FK506) is a potent immunosuppressant that prevents T-cell proliferation produced solely by Streptomyces species. We report here the first draft genome sequence of a true FK506 producer, Streptomyces tsukubaensis NRRL 18488, the first tacrolimus-producing strain that was isolated and that contains the full tacrolimus biosynthesis gene cluster. |
| PubMedSearch : Barreiro_2012_J.Bacteriol_194_3756 |
| PubMedID: 22740677 |
| Gene_locus related to this paper: 9acto-i2naa3 , 9acto-i2mwy7 , strt9-i2myj3 , strt9-a0a7g3u7a3 , strt9-a0a7g3uf98 , strt9-a0a7g3ufb8 |
Barreiro C, Prieto C, Sola-Landa A, Solera E, Martinez-Castro M, Perez-Redondo R, Garcia-Estrada C, Aparicio JF, Fernandez-Martinez LT, Santos-Aberturas J, Salehi-Najafabadi Z, Rodriguez-Garcia A, Tauch A, Martin JF (2012)
Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506)
Journal of Bacteriology
194 :3756
Barreiro C, Prieto C, Sola-Landa A, Solera E, Martinez-Castro M, Perez-Redondo R, Garcia-Estrada C, Aparicio JF, Fernandez-Martinez LT, Santos-Aberturas J, Salehi-Najafabadi Z, Rodriguez-Garcia A, Tauch A, Martin JF (2012)
Journal of Bacteriology
194 :3756