Bartolomeo_1997_Neurobiol.Learn.Mem_68_333

Reference

Title : Arecoline via miniosmotic pump improves AF64A-impaired radial maze performance in rats: a possible model of Alzheimer's disease - Bartolomeo_1997_Neurobiol.Learn.Mem_68_333
Author(s) : Bartolomeo AC , Morris H , Boast CA
Ref : Neurobiol Learn Mem , 68 :333 , 1997
Abstract :

Male Sprague-Dawley rats, preoperatively trained in a 1-h delay non-match-to-position radial maze task, received bilateral stereotaxic injections of a selective cholinotoxin, ethylcholine aziridinium ion (AF64A: 3 nmol/3 microliters/lateral ventricle). Animals treated with AF64A made significantly more total postdelay errors than vehicle controls. Sustained delivery, via miniosmotic pumps, of arecoline (0.1, 0.3, 1, 3, 10, or 30 mg/kg/day sc for 14 days) attenuated the AF64A-induced cognitive impairment in a dose-dependent manner, producing an inverted U-shaped dose-response function which was optimal at 1.0 mg/kg/day. Following these studies, choline acetyltransferase activity was significantly reduced in hippocampi extracted from the AF64A-treated rats, indicating successful cholinotoxicity. This paradigm may be useful as a possible screen for potential Alzheimer's disease therapeutic agents. This conclusion is supported by published reports of beneficial arecoline effects observed following 2-week intravenous infusions in patients with Alzheimer's disease (Soncrant, Raffaele, Asthana, Berardi, Morris, & Haxby, 1993).

PubMedSearch : Bartolomeo_1997_Neurobiol.Learn.Mem_68_333
PubMedID: 9398593

Related information

Substrate Arecoline

Citations formats

Bartolomeo AC, Morris H, Boast CA (1997)
Arecoline via miniosmotic pump improves AF64A-impaired radial maze performance in rats: a possible model of Alzheimer's disease
Neurobiol Learn Mem 68 :333

Bartolomeo AC, Morris H, Boast CA (1997)
Neurobiol Learn Mem 68 :333