| Title : Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change - Bartsch_1995_Cell_83_979 |
| Author(s) : Bartsch D , Ghirardi M , Skehel PA , Karl KA , Herder SP , Chen M , Bailey CH , Kandel ER |
| Ref : Cell , 83 :979 , 1995 |
|
Abstract :
The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4. ApCREB2 represses ApCREB1-mediated transcription in F9 cells. Injection of anti-ApCREB2 antibodies into Aplysia sensory neurons causes a single pulse of serotonin (5-HT), which induces only short-term facilitation lasting minutes, to evoke facilitation lasting more than 1 day. This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT. |
| PubMedSearch : Bartsch_1995_Cell_83_979 |
| PubMedID: 8521521 |
Bartsch D, Ghirardi M, Skehel PA, Karl KA, Herder SP, Chen M, Bailey CH, Kandel ER (1995)
Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change
Cell
83 :979
Bartsch D, Ghirardi M, Skehel PA, Karl KA, Herder SP, Chen M, Bailey CH, Kandel ER (1995)
Cell
83 :979