| Title : Regioselective hydrolysis of peracetylated alpha-D-glycopyranose catalyzed by immobilized lipases in aqueous medium. A facile preparation of useful intermediates for oligosaccharide synthesis - Bastida_1999_Bioorg.Med.Chem.Lett_9_633 |
| Author(s) : Bastida A , Fernandez-Lafuente R , Fernandez-Lorente G , Guisan JM , Pagani G , Terreni M |
| Ref : Bioorganic & Medicinal Chemistry Lett , 9 :633 , 1999 |
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Abstract :
Penta-O-acetyl-alpha-D-glucopyranose was selectively deacetylated in aqueous media by lipases from Candida cilindracea (CCL) adsorbed on octyl-agarose support. Enzymatic hydrolyses was regioselective at the 4-position under neutral pH and towards the 6 position under acidic conditions. This enzymatic approach allows the one step synthesis of 1,2,3,6-tetra-O-acetyl-alpha-D-glucopyranoses 1, a useful intermediate in oligosaccharide synthesis. |
| PubMedSearch : Bastida_1999_Bioorg.Med.Chem.Lett_9_633 |
| PubMedID: 10098679 |
| Substrate | Glucose-pentaacetate |
Bastida A, Fernandez-Lafuente R, Fernandez-Lorente G, Guisan JM, Pagani G, Terreni M (1999)
Regioselective hydrolysis of peracetylated alpha-D-glycopyranose catalyzed by immobilized lipases in aqueous medium. A facile preparation of useful intermediates for oligosaccharide synthesis
Bioorganic & Medicinal Chemistry Lett
9 :633
Bastida A, Fernandez-Lafuente R, Fernandez-Lorente G, Guisan JM, Pagani G, Terreni M (1999)
Bioorganic & Medicinal Chemistry Lett
9 :633