| Title : The green synthesis and molecular docking of novel N-substituted rhodanines as effective inhibitors for carbonic anhydrase and acetylcholinesterase enzymes - Bayindir_2019_Bioorg.Chem_90_103096 |
| Author(s) : Bayindir S , Caglayan C , Karaman M , Gulcin I |
| Ref : Bioorg Chem , 90 :103096 , 2019 |
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Abstract :
Recently, inhibition effects of enzymes such as acetylcholinesterase (AChE) and carbonic anhydrase (CA) has appeared as a promising approach for pharmacological intervention in a variety of disorders such as epilepsy, Alzheimer's disease and obesity. For this purpose, novel N-substituted rhodanine derivatives (RhAs) were synthesized by a green synthetic approach over one-pot reaction. Following synthesis the novel compounds, RhAs derivatives were tested against AChE and cytosolic carbonic anhydrase I, and II (hCAs I, and II) isoforms. As a result of this study, inhibition constant (Ki) were found in the range of 66.35+/-8.35 to 141.92+/-12.63nM for AChE, 43.55+/-14.20 to 89.44+/-24.77nM for hCA I, and 16.97+/-1.42 to 64.57+/-13.27nM for hCA II, respectively. Binding energies were calculated with docking studies as -5.969, -5.981, and -9.121kcal/mol for hCA I, hCA II, and AChE, respectively. |
| PubMedSearch : Bayindir_2019_Bioorg.Chem_90_103096 |
| PubMedID: 31284100 |
Bayindir S, Caglayan C, Karaman M, Gulcin I (2019)
The green synthesis and molecular docking of novel N-substituted rhodanines as effective inhibitors for carbonic anhydrase and acetylcholinesterase enzymes
Bioorg Chem
90 :103096
Bayindir S, Caglayan C, Karaman M, Gulcin I (2019)
Bioorg Chem
90 :103096