| Title : Nostocarboline: isolation and synthesis of a new cholinesterase inhibitor from Nostoc 78-12A - Becher_2005_J.Nat.Prod_68_1793 |
| Author(s) : Becher PG , Beuchat J , Gademann K , Juttner F |
| Ref : Journal of Natural Products , 68 :1793 , 2005 |
| Abstract : A new quaternary beta-carboline alkaloid, nostocarboline, was isolated from the freshwater cyanobacterium Nostoc 78-12A, and its constitution was assigned by 2D-NMR methods. The structure was proven by its total synthesis starting from norharmane via chlorination at C-6 and methylation at N-2. Nostocarboline was found to be a potent butyrylcholinesterase (BChE) inhibitor, with an IC(50) of 13.2 microM. The related 2-methylnorharmane, which is present in the human brain and might be relevant to Parkinson's disease (PD), was also determined to be a BChE inhibitor (11.2 microM). These inhibitory concentrations are comparable to galanthamine, an approved drug for the treatment of Alzheimer's disease (AD). Nostocarboline can thus be considered as a lead for the development of novel neurochemicals. |
| ESTHER : Becher_2005_J.Nat.Prod_68_1793 |
| PubMedSearch : Becher_2005_J.Nat.Prod_68_1793 |
| PubMedID: 16378379 |
Becher PG, Beuchat J, Gademann K, Juttner F (2005)
Nostocarboline: isolation and synthesis of a new cholinesterase inhibitor from Nostoc 78-12A
Journal of Natural Products
68 :1793
Becher PG, Beuchat J, Gademann K, Juttner F (2005)
Journal of Natural Products
68 :1793