Behl_2007_Arch.Neurol_64_266

Reference

Title : Strategic subcortical hyperintensities in cholinergic pathways and executive function decline in treated Alzheimer patients - Behl_2007_Arch.Neurol_64_266
Author(s) : Behl P , Bocti C , Swartz RH , Gao F , Sahlas DJ , Lanctot KL , Streiner DL , Black SE
Ref : Archives of Neurology , 64 :266 , 2007
Abstract :

OBJECTIVE: To investigate changes in cognition, function, and behavior after 1 year in patients with Alzheimer disease being treated with cholinesterase inhibitors, in relation to the presence or absence of subcortical hyperintensities involving the cholinergic pathways. DESIGN: One-year prospective cohort study. SETTING: Memory Clinic, Sunnybrook Health Sciences Centre, University of Toronto. Patients Ninety patients with possible/probable Alzheimer disease who were being treated with cholinesterase inhibitors at baseline. INTERVENTIONS: Yearly standardized neuropsychological testing and brain magnetic resonance imaging (MRI). The Cholinergic Pathways Hyperintensities Scale (CHIPS) was applied to baseline MRIs to rate the severity of subcortical hyperintensities in cholinergic pathways. The consensus-derived Age-Related White Matter Changes (ARWMC) Rating Scale was used as a general measure of white matter disease burden. MAIN OUTCOME MEASURES: Tests of global cognition, function, and behavior and specific cognitive and functional domains. RESULTS: Patients in the low CHIPS group were equivalent to those in the high CHIPS group with regard to baseline demographic characteristics, cognitive severity, and vascular risk factors. After covarying age and education, no differences were found after 1 year in overall cognition, function, and behavior or on memory, language, and visuospatial tasks. Patients in the high CHIPS group showed improvement on executive function and working memory tasks compared with those in the low CHIPS group. For the ARWMC scale, groups with and without white matter abnormalities were equivalent on baseline demographics and in cognitive, functional, and behavioral outcomes. CONCLUSION: Cerebrovascular compromise of the cholinergic pathways may be a factor that contributes more selectively than does total white matter lesion burden to response to cholinergic therapy in Alzheimer disease, particularly on frontal/executive tasks.

PubMedSearch : Behl_2007_Arch.Neurol_64_266
PubMedID: 17296844

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Citations formats

Behl P, Bocti C, Swartz RH, Gao F, Sahlas DJ, Lanctot KL, Streiner DL, Black SE (2007)
Strategic subcortical hyperintensities in cholinergic pathways and executive function decline in treated Alzheimer patients
Archives of Neurology 64 :266

Behl P, Bocti C, Swartz RH, Gao F, Sahlas DJ, Lanctot KL, Streiner DL, Black SE (2007)
Archives of Neurology 64 :266