| Title : HLA-DQ beta-chain polymorphism linked to myasthenia gravis - Bell_1986_Lancet_1_1058 |
| Author(s) : Bell J , Rassenti L , Smoot S , Smith K , Newby C , Hohlfeld R , Toyka K , McDevitt H , Steinman L |
| Ref : Lancet , 1 :1058 , 1986 |
|
Abstract :
The HLA-DR3 haplotype is associated with increased risk of myasthenia gravis (MG) and a number of other autoimmune diseases, including insulin-dependent diabetes mellitus (IDDM), coeliac disease, and premature ovarian failure (POF). With a cDNA probe for a DQ beta gene, a 15 kb Hinc II restriction fragment has been demonstrated in genomic DNA from 7 of 16 HLA-DR3 patients with MG, 1 of 19 healthy DR3 controls, and none of 24 DR3 patients with IDDM, coeliac disease, or POF. The HLA-DQ polymorphism may be closely linked to a genetic locus regulating immune responsiveness to acetylcholine receptor and susceptibility to MG. |
| PubMedSearch : Bell_1986_Lancet_1_1058 |
| PubMedID: 2871336 |
Bell J, Rassenti L, Smoot S, Smith K, Newby C, Hohlfeld R, Toyka K, McDevitt H, Steinman L (1986)
HLA-DQ beta-chain polymorphism linked to myasthenia gravis
Lancet
1 :1058
Bell J, Rassenti L, Smoot S, Smith K, Newby C, Hohlfeld R, Toyka K, McDevitt H, Steinman L (1986)
Lancet
1 :1058