| Title : Immunoperoxidase localization of alpha bungarotoxin: a new approach to myasthenia gravis - Bender_1976_Ann.N.Y.Acad.Sci_274_20 |
| Author(s) : Bender AN , Ringel SP , Engel WK , Vogel Z , Daniels MP |
| Ref : Annals of the New York Academy of Sciences , 274 :20 , 1976 |
| Abstract : The IPBT method has made it possible to precisely visualize the AChR. Normal distribution of AChR is at the peaks of the postjunctional folds of the muscle sarcolemmal membrane with a small amount present on the axonal tip as well. Denervated muscle fibers have extrajunctional AChR. In MG, there are also denervated-appearing fibers but these do not have extrajuctional AChR with the IPBT stain. To explain this, we have been able to demonstrate a serum factor capable of blocking the binding of alpha-BuTx to the AChR and have shown for the first time that this factor is capable of acting at the neuromuscular junction itself. This blocking factor may play a major role in causing the weakness of MG. |
| ESTHER : Bender_1976_Ann.N.Y.Acad.Sci_274_20 |
| PubMedSearch : Bender_1976_Ann.N.Y.Acad.Sci_274_20 |
| PubMedID: 60894 |
Bender AN, Ringel SP, Engel WK, Vogel Z, Daniels MP (1976)
Immunoperoxidase localization of alpha bungarotoxin: a new approach to myasthenia gravis
Annals of the New York Academy of Sciences
274 :20
Bender AN, Ringel SP, Engel WK, Vogel Z, Daniels MP (1976)
Annals of the New York Academy of Sciences
274 :20