Bernieri_2019_Drug.Chem.Toxicol__1

Reference

Title : Effect of pesticide exposure on total antioxidant capacity and biochemical parameters in Brazilian soybean farmers - Bernieri_2019_Drug.Chem.Toxicol__1
Author(s) : Bernieri T , Rodrigues D , Randon Barbosa I , Perassolo MS , Grolli Ardenghi P , Basso da Silva L
Ref : Drug & Chemical Toxicology , :1 , 2019
Abstract :

Farmers represent a population highly vulnerable to the toxic effects of pesticide exposure. Antioxidant capacity and biochemical parameters have been used as biomarkers of occupational exposure to pesticides. The aim of this study was to evaluate hepatic and renal parameters as well as butyrylcholinesterase (BChE) activity and ferric-reducing ability of plasma (FRAP) considering high and low exposure periods in soybean farmers in southern Brazil. The exposed group consisted of 50 soybean farmers. Two control groups were used, composed by 35 (Novo Hamburgo control group) and 28 (Sertao control group) subjects not exposed to pesticides. Farmers blood samples were collected during the high and low pesticide exposure periods. BChE, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), urea, and creatinine levels were determined. The FRAP assay was carried out to evaluate the antioxidant potential in the exposed group. Considering the exposed group, significantly lower BChE and increased AST activity were observed during high pesticide exposure period as well as higher FRAP, urea and creatinine levels; however, ALT and GGT did not differ between the two periods. When compared with the control groups, only urea and creatinine were higher in the exposed group. The present results indicate that occupational exposure to mixtures of pesticides might elicit adverse effects at the biochemical level. In addition, the study highlights the importance in considering periods of a same crop season with different degree of pesticide exposure during biologic monitoring of these biochemical parameters.

PubMedSearch : Bernieri_2019_Drug.Chem.Toxicol__1
PubMedID: 30950301

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Citations formats

Bernieri T, Rodrigues D, Randon Barbosa I, Perassolo MS, Grolli Ardenghi P, Basso da Silva L (2019)
Effect of pesticide exposure on total antioxidant capacity and biochemical parameters in Brazilian soybean farmers
Drug & Chemical Toxicology :1

Bernieri T, Rodrigues D, Randon Barbosa I, Perassolo MS, Grolli Ardenghi P, Basso da Silva L (2019)
Drug & Chemical Toxicology :1