| Title : Solubilization and characterization of high and low affinity pirenzepine binding sites from rat cerebral cortex - Berrie_1985_Br.J.Pharmacol_85_697 |
| Author(s) : Berrie CP , Birdsall NJ , Hulme EC , Keen M , Stockton JM |
| Ref : British Journal of Pharmacology , 85 :697 , 1985 |
|
Abstract :
An apparently monomeric form of the digitonin-solubilized muscarinic acetylcholine receptor from the rat cerebral cortex retains a high affinity of 7 X 10(7) M-1 for pirenzepine. Muscarinic receptor binding sites in the rat cerebral cortex with a low affinity for pirenzepine are solubilized with relatively little change in affinity. The ability of pirenzepine to distinguish between subtypes of muscarinic binding site in the cerebral cortex is manifest in both the membrane-bound and soluble state. |
| PubMedSearch : Berrie_1985_Br.J.Pharmacol_85_697 |
| PubMedID: 4027484 |
Berrie CP, Birdsall NJ, Hulme EC, Keen M, Stockton JM (1985)
Solubilization and characterization of high and low affinity pirenzepine binding sites from rat cerebral cortex
British Journal of Pharmacology
85 :697
Berrie CP, Birdsall NJ, Hulme EC, Keen M, Stockton JM (1985)
British Journal of Pharmacology
85 :697