| Title : A New Berberine Preparation Protects Pancreatic Islet Cells from Apoptosis Mediated by Inhibition of Phospholipase A(2)\/p38 MAPK Pathway - Bi_2022_Bull.Exp.Biol.Med_173_346 |
| Author(s) : Bi XJ , Lv YQ , Yang XH , Ge Y , Han H , Feng JS , Zhang M , Chen L , Xu MZ , Guan FY |
| Ref : Bulletin of Experimental Biology & Medicine , 173 :346 , 2022 |
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Abstract :
We studied an amorphous solid dispersion of berberine with absorption enhancer sodium caprate (Huang-Gui solid dispersion preparations, HGSD). A therapeutic effect of HGSD was revealed in mice with type 2 diabetes mellitus and palmitate-induced injury to MIN6 beta-cells. HGSD treatment (150 mg/kg) improved glucose metabolism and decreased beta-cell apoptosis in diabetic mice. Furthermore, the effective component of HGSD berberine significantly attenuated the palmitate-induced decrease in MIN6 beta-cells viability and insulin secretion. Moreover, molecular docking analysis and Western blotting showed that berberine decreased cell apoptosis and expression of group VIA phospholipase A(2) (iPLA(2)), p38 mitogen-activated protein kinase (p38 MAPK), and caspase-3. These data suggest that HGSD treatment protected beta-cells via inhibiting the iPLA(2)/p38 MAPK pathway. |
| PubMedSearch : Bi_2022_Bull.Exp.Biol.Med_173_346 |
| PubMedID: 35852692 |
Bi XJ, Lv YQ, Yang XH, Ge Y, Han H, Feng JS, Zhang M, Chen L, Xu MZ, Guan FY (2022)
A New Berberine Preparation Protects Pancreatic Islet Cells from Apoptosis Mediated by Inhibition of Phospholipase A(2)\/p38 MAPK Pathway
Bulletin of Experimental Biology & Medicine
173 :346
Bi XJ, Lv YQ, Yang XH, Ge Y, Han H, Feng JS, Zhang M, Chen L, Xu MZ, Guan FY (2022)
Bulletin of Experimental Biology & Medicine
173 :346