| Title : Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors - Bianchi_2005_Bioorg.Med.Chem.Lett_15_2711 |
| Author(s) : Bianchi DA , Hirschmann GS , Theoduloz C , Bracca AB , Kaufman TS |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2711 , 2005 |
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Abstract :
The synthesis of simplified analogs of the novel isoquinoline alkaloid stephaoxocanidine, carrying the oxazaphenalene ABC-ring system of the natural product, and their activity as inhibitors of the enzyme acetylcholinesterase, are reported. 5,6-Dimethoxy-7H -8-oxa-1-aza-phenalen-9-one (5) was as active as a Narcissus extract enriched in galantamine. |
| PubMedSearch : Bianchi_2005_Bioorg.Med.Chem.Lett_15_2711 |
| PubMedID: 15878275 |
Bianchi DA, Hirschmann GS, Theoduloz C, Bracca AB, Kaufman TS (2005)
Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry Lett
15 :2711
Bianchi DA, Hirschmann GS, Theoduloz C, Bracca AB, Kaufman TS (2005)
Bioorganic & Medicinal Chemistry Lett
15 :2711