| Title : Functional evidence that acetylcholine release from Auerbach's plexus of guinea-pig ileum is modulated by alpha 2A-adrenoceptor subtype - Blandizzi_1991_Eur.J.Pharmacol_205_311 |
| Author(s) : Blandizzi C , Doda M , Tarkovacs G , Del Tacca M , Vizi ES |
| Ref : European Journal of Pharmacology , 205 :311 , 1991 |
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Abstract :
The effects of alpha 2-adrenoceptor ligands on electrically stimulated [3H]acetylcholine release from longitudinal muscle strips of guinea-pig ileum were examined. Xylazine or oxymetazoline reduced the release of [3H]acetylcholine in a concentration-dependent manner, both these actions being antagonized by idazoxan, CH 38083, or WB 4101. Prazosin, considered as an alpha 2B-adrenoceptor antagonist, failed to modify the inhibitory effects of xylazine or oxymetazoline. It is concluded that the alpha 2-adrenoceptors involved in the modulation of acetylcholine release from cholinergic axon terminals of guinea-pig ileum are of the alpha 2A subtype. |
| PubMedSearch : Blandizzi_1991_Eur.J.Pharmacol_205_311 |
| PubMedID: 1667916 |
Blandizzi C, Doda M, Tarkovacs G, Del Tacca M, Vizi ES (1991)
Functional evidence that acetylcholine release from Auerbach's plexus of guinea-pig ileum is modulated by alpha 2A-adrenoceptor subtype
European Journal of Pharmacology
205 :311
Blandizzi C, Doda M, Tarkovacs G, Del Tacca M, Vizi ES (1991)
European Journal of Pharmacology
205 :311