| Title : Silanetriols as in vitro inhibitors for AChE - Blunder_2011_Bioorg.Med.Chem.Lett_21_363 |
| Author(s) : Blunder M , Hurkes N , Spirk S , List M , Pietschnig R |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :363 , 2011 |
| Abstract : Three stable silanetriols with increasing steric protection of the silicon atom have been tested for inhibition of acetylcholinesterase (AChE). For all tested silanetriols we found reversible inhibition of the AChE activity at a 100 muM concentration. The highest inhibition rate was found for the sterically least hindered cyclohexylsilanetriol with 45% inhibition relative to galanthamine hydrobromide for which an IC(50) value of 121 +/- 3 muM was determined as well. The cytotoxicity of the silanetriols used was found to be negligible at concentrations relevant for inhibition. |
| ESTHER : Blunder_2011_Bioorg.Med.Chem.Lett_21_363 |
| PubMedSearch : Blunder_2011_Bioorg.Med.Chem.Lett_21_363 |
| PubMedID: 21111617 |
Blunder M, Hurkes N, Spirk S, List M, Pietschnig R (2011)
Silanetriols as in vitro inhibitors for AChE
Bioorganic & Medicinal Chemistry Lett
21 :363
Blunder M, Hurkes N, Spirk S, List M, Pietschnig R (2011)
Bioorganic & Medicinal Chemistry Lett
21 :363