| Title : Use of differentiated cholinergic and second messenger endpoints to evaluate cholinesterase inhibitors - Blusztajn_1995_Clin.Exp.Pharmacol.Physiol_22_368 |
| Author(s) : Blusztajn JK , Davis RO |
| Ref : Clinical & Experimental Pharmacology & Physiology , 22 :368 , 1995 |
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Abstract :
1. The effects of organophosphorus compounds on the cholinergic properties of a mouse septal neuronal cell line, SN56, were investigated. Treatment of the cells with 10 mumol/L paraoxon or 10 mumol/L diisopropylphosphorofluoridate (DFP) resulted, respectively, in rapid 27- and 11-fold increases of intracellular acetylcholine content. 2. Time-course studies showed that paraoxon maintained its efficacy whereas the effects of DFP decayed quickly, possibly due to rapid hydrolysis and inactivation of DFP in the growth medium. |
| PubMedSearch : Blusztajn_1995_Clin.Exp.Pharmacol.Physiol_22_368 |
| PubMedID: 7554433 |
Blusztajn JK, Davis RO (1995)
Use of differentiated cholinergic and second messenger endpoints to evaluate cholinesterase inhibitors
Clinical & Experimental Pharmacology & Physiology
22 :368
Blusztajn JK, Davis RO (1995)
Clinical & Experimental Pharmacology & Physiology
22 :368