Boll_2020_Environ.Microbiol.Rep_12_3

Reference

Title : Microbial degradation of phthalates: biochemistry and environmental implications - Boll_2020_Environ.Microbiol.Rep_12_3
Author(s) : Boll M , Geiger R , Junghare M , Schink B
Ref : Environ Microbiol Rep , 12 :3 , 2020
Abstract :

The environmentally relevant xenobiotic esters of phthalic acid (PA), isophthalic acid (IPA) and terephthalic acid (TPA) are produced on a million ton scale annually and are predominantly used as plastic polymers or plasticizers. Degradation by microorganisms is considered as the most effective means of their elimination from the environment and proceeds via hydrolysis to the corresponding PA isomers and alcohols under oxic and anoxic conditions. Further degradation of PA, IPA and TPA differs fundamentally between anaerobic and aerobic microorganisms. The latter introduce hydroxyl functionalities by dioxygenases to facilitate subsequent decarboxylation by either aromatizing dehydrogenases or cofactor-free decarboxylases. In contrast, anaerobic bacteria activate the PA isomers to the respective thioesters using CoA ligases or CoA transferases followed by decarboxylation to the central intermediate benzoyl-CoA. Decarboxylases acting on the three PA CoA thioesters belong to the UbiD enzyme family that harbour a prenylated flavin mononucleotide (FMN) cofactor to achieve the mechanistically challenging decarboxylation. Capture of the extremely instable PA-CoA intermediate is accomplished by a massive overproduction of phthaloyl-CoA decarboxylase and a balanced production of PA-CoA forming/decarboxylating enzymes. The strategy of anaerobic phthalate degradation probably represents a snapshot of an ongoing evolution of a xenobiotic degradation pathway via a short-lived reaction intermediate.

PubMedSearch : Boll_2020_Environ.Microbiol.Rep_12_3
PubMedID: 31364812

Related information

Citations formats

Boll M, Geiger R, Junghare M, Schink B (2020)
Microbial degradation of phthalates: biochemistry and environmental implications
Environ Microbiol Rep 12 :3

Boll M, Geiger R, Junghare M, Schink B (2020)
Environ Microbiol Rep 12 :3