Bon_1985_Neurochem.Int_7_63

Reference

Title : Partial purification of alpha-glycerotoxin, a presynaptic neurotoxin from the venom glands of the polychaete annelid glycera convoluta - Bon_1985_Neurochem.Int_7_63
Author(s) : Bon C , Saliou B , Thieffry M , Manaranche R
Ref : Neurochem Int , 7 :63 , 1985
Abstract :

The venom secreted from glands appended to the jaws of Glycera convoluta, a Polychaete Annelid, increases the spontaneous quantal release of transmitter from nerve terminals. The component that is biologically active on vertebrate cholinergic nerve terminals has recently been shown to be a high molecular weight protein. In the present work, the crude extract from the venom apparatus was shown to be toxic for mammals and crustaceans. It was fractionated by gel filtrations and ion exchange chromatographies. The biologically active component at frog neuromuscular junctions, alpha-glycerotoxin, was purified more than 1,000-fold. It is distinct from the components that are toxic for crustaceans. Purified alpha-glycerotoxin is a globular protein of 300,000 +/- 20,000 mol wt. It has a Stokes radius of 65 A and a sedimentation coefficient of 11 S. By its molecular properties, alpha-glycerotoxin appears distinct from other neurotoxins such as alpha-latrotoxin, which also trigger transmitter release.

PubMedSearch : Bon_1985_Neurochem.Int_7_63
PubMedID: 20492900

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Citations formats

Bon C, Saliou B, Thieffry M, Manaranche R (1985)
Partial purification of alpha-glycerotoxin, a presynaptic neurotoxin from the venom glands of the polychaete annelid glycera convoluta
Neurochem Int 7 :63

Bon C, Saliou B, Thieffry M, Manaranche R (1985)
Neurochem Int 7 :63