Bonafe_2002_Eur.J.Hum.Genet_10_292

Reference

Title : Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians - Bonafe_2002_Eur.J.Hum.Genet_10_292
Author(s) : Bonafe M , Marchegiani F , Cardelli M , Olivieri F , Cavallone L , Giovagnetti S , Pieri C , Marra M , Antonicelli R , Troiano L , Gueresi P , Passeri G , Berardelli M , Paolisso G , Barbieri M , Tesei S , Lisa R , De Benedictis G , Franceschi C
Ref : Eur J Hum Genet , 10 :292 , 2002
Abstract :

Human Paraoxonase (PON1) is a High-Density Lipoprotein (HDL)-associated esterase that hydrolyses lipo-peroxides. PON1 has recently attracted attention as a protective factor against oxidative modification of LDL and may therefore play an important role in the prevention of the atherosclerotic process. Two polymorphisms have been extensively studied: a Leucine (L allele) to Methionine (M allele) substitution at codon 55, and a Glutamine (A allele) to Arginine (B allele) substitution at codon 192. We have examined these two aminoacidic changes in 579 people aged 20 to 65 years old, and 308 centenarians. We found that the percentage of carriers of the B allele at codon 192 (B+ individuals) is higher in centenarians than in controls (0.539 vs 0.447), moreover we found that among the B+ individuals, the phenomenon was due to an increase of people carrying M alleles at codon 55 locus. In conclusion, we propose that genetic variability at PON1 locus affects survival at extreme advanced age.

PubMedSearch : Bonafe_2002_Eur.J.Hum.Genet_10_292
PubMedID: 12082503

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Citations formats

Bonafe M, Marchegiani F, Cardelli M, Olivieri F, Cavallone L, Giovagnetti S, Pieri C, Marra M, Antonicelli R, Troiano L, Gueresi P, Passeri G, Berardelli M, Paolisso G, Barbieri M, Tesei S, Lisa R, De Benedictis G, Franceschi C (2002)
Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians
Eur J Hum Genet 10 :292

Bonafe M, Marchegiani F, Cardelli M, Olivieri F, Cavallone L, Giovagnetti S, Pieri C, Marra M, Antonicelli R, Troiano L, Gueresi P, Passeri G, Berardelli M, Paolisso G, Barbieri M, Tesei S, Lisa R, De Benedictis G, Franceschi C (2002)
Eur J Hum Genet 10 :292