| Title : T-lymphocyte interferon-gamma receptor binding in patients with myasthenia gravis - Bongioanni_1999_Arch.Neurol_56_933 |
| Author(s) : Bongioanni P , Ricciardi R , Romano MR |
| Ref : Archives of Neurology , 56 :933 , 1999 |
| Abstract : OBJECTIVE: To investigate some aspects of T-lymphocyte-dependent immune function in patients with myasthenia gravis (MG). DESIGN: Assay interferon-gamma binding on T lymphocytes from patients with MG compared with healthy controls. SETTING: The study was performed on ambulatory patients in a tertiary care center, where MG was diagnosed according to Osserman criteria. PATIENTS: Thirty-six patients with MG (19 women and 17 men; mean +/- SD age, 50.2+/-17.6 years) were selected consecutively. They were assigned to groups 1, 2A, and 2B. Ten patients were treated with pyridostigmine bromide alone, 18 were treated with pyridostigmine and corticosteroids, and 8 were not yet treated. Thirty-six age-and sex-matched healthy nonsmoking subjects formed the control group. RESULTS: A significant (P<.001) decrease of T-lymphocyte interferon-gamma binding was found in patients with MG compared with healthy controls (483+/-14 vs. 734+/-13 receptors [SEM] per cell), whereas the ligand-receptor affinity values [SEM] were similar in the 2 groups (0.9+/-0.05 and 1.0+/-0.07 nmol/L). CONCLUSION: These data indicate a persistent activation of the immune system in patients with MG, since reduced cell surface interferon-gamma receptors seem to be related with enhanced T-lymphocyte immune function. |
| ESTHER : Bongioanni_1999_Arch.Neurol_56_933 |
| PubMedSearch : Bongioanni_1999_Arch.Neurol_56_933 |
| PubMedID: 10448798 |
Bongioanni P, Ricciardi R, Romano MR (1999)
T-lymphocyte interferon-gamma receptor binding in patients with myasthenia gravis
Archives of Neurology
56 :933
Bongioanni P, Ricciardi R, Romano MR (1999)
Archives of Neurology
56 :933