| Title : Comparative properties of N-acetyl derivatives of oxime N-methylcarbamates and aryl N-methylcarbamates as insecticides and acetylcholinesterase inhibitors - Boulton_1971_Pest.Sci_2_10 |
| Author(s) : Boulton JJK , Boyce CBC , Jewess PJ , Jones RF |
| Ref : Pest Sci , 2 :10 , 1971 |
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Abstract :
N-acylation of aryl N-methylcarbamates is known to reduce their mammalian toxicity considerably without adversely affecting their insecticidal activity. It has now been found that N-acylation of several insecticidal oxime carbamates results in loss of toxicity both to insects and mammals. Kinetic data for base-catalysed solvolysis and inhibition of acetylcholinesterase, together with published work on metabolism, are combined to provide a rationale for this unexpected observation and to account for the selective toxicity of aryl N-acetyl-N-methylcarbamates. |
| PubMedSearch : Boulton_1971_Pest.Sci_2_10 |
| PubMedID: |
Boulton JJK, Boyce CBC, Jewess PJ, Jones RF (1971)
Comparative properties of N-acetyl derivatives of oxime N-methylcarbamates and aryl N-methylcarbamates as insecticides and acetylcholinesterase inhibitors
Pest Sci
2 :10
Boulton JJK, Boyce CBC, Jewess PJ, Jones RF (1971)
Pest Sci
2 :10