| Title : Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins - Brayton_2005_Proc.Natl.Acad.Sci.U.S.A_102_844 |
| Author(s) : Brayton KA , Kappmeyer LS , Herndon DR , Dark MJ , Tibbals DL , Palmer GH , McGuire TC , Knowles DP, Jr. |
| Ref : Proc Natl Acad Sci U S A , 102 :844 , 2005 |
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Abstract :
The rickettsia Anaplasma marginale is the most prevalent tick-borne livestock pathogen worldwide and is a severe constraint to animal health. A. marginale establishes lifelong persistence in infected ruminants and these animals serve as a reservoir for ticks to acquire and transmit the pathogen. Within the mammalian host, A. marginale generates antigenic variants by changing a surface coat composed of numerous proteins. By sequencing and annotating the complete 1,197,687-bp genome of the St. Maries strain of A. marginale, we show that this surface coat is dominated by two families containing immunodominant proteins: the msp2 superfamily and the msp1 superfamily. Of the 949 annotated coding sequences, just 62 are predicted to be outer membrane proteins, and of these, 49 belong to one of these two superfamilies. The genome contains unusual functional pseudogenes that belong to the msp2 superfamily and play an integral role in surface coat antigenic variation, and are thus distinctly different from pseudogenes described as byproducts of reductive evolution in other Rickettsiales. |
| PubMedSearch : Brayton_2005_Proc.Natl.Acad.Sci.U.S.A_102_844 |
| PubMedID: 15618402 |
| Gene_locus related to this paper: anamm-q5pbf4 , anamm-q5pbl2 , anamm-q5pbs6 |
| Gene_locus | anamm-q5pbf4 anamm-q5pbl2 anamm-q5pbs6 |
Brayton KA, Kappmeyer LS, Herndon DR, Dark MJ, Tibbals DL, Palmer GH, McGuire TC, Knowles DP, Jr. (2005)
Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins
Proc Natl Acad Sci U S A
102 :844
Brayton KA, Kappmeyer LS, Herndon DR, Dark MJ, Tibbals DL, Palmer GH, McGuire TC, Knowles DP, Jr. (2005)
Proc Natl Acad Sci U S A
102 :844