Bretaud_2002_Environ.Toxicol.Chem_21_175

The effects of concentration 5 50 and 500 microg/L and duration 24 48 h of exposure to carbofuran a carbamate insecticide were assessed on brain catecholamine norepinephrine NE and dopamine plasma glucose and hepatic glycogen contents and behavioral activities of goldfish Carassius auratus After 24 h of exposure to 50 and 500 microg/L the level of NE was increased in the olfactory bulbs The same effect was observed after a 48-h exposure to 500 and 50 microg/L in the telencephalic hemispheres and in the hypothalamus respectively An increase in the level of dopamine was also found in hypothalamus after 48 h of exposure to 500 microg/L carbofuran Plasma glucose increased in concentration after both periods of exposure to carbofuran at 50 and 500 microg/L Hepatic glycogen concentration decreased after a 48-h exposure to the highest concentration Behavioral endpoints related to swimming pattern and social interactions were affected after a 24-h exposure to the lowest concentration tested 5 microg/L The relative sensitivities of these different types of responses to exposure to carbofuran are discussed in light of data on the neurotoxic effects of carbamate and organophosphate insecticides in fish