Title : The role of brain acetylcholine in the pressor response to centrally infected neostigmine - Brezenoff_1973_Br.J.Pharmacol_49_557 |
Author(s) : Brezenoff HE |
Ref : British Journal of Pharmacology , 49 :557 , 1973 |
Abstract :
In unanaesthetized rats, neostigmine (2.5 mug) injected into the cerebral ventricles produces a rise in arterial blood pressure. The effect on the rise was examined after lowering the acetylcholine (ACh) level of the brain by hemicholinium (HC-3) similarly injected.The pressor response was not significantly altered 2 h after injection of 50 mug HC-3 when the ACh level was reduced by 54%. It was greatly attenuated 2 h after injection of 75 mug when the ACh level was reduced by 76%. However, a similar attenuation was observed as early as 30 min after this injection when the ACh level was reduced by 18% only.It is concluded that the pressor response is not mediated by undestroyed ACh but is a direct central effect of neostigmine. |
PubMedSearch : Brezenoff_1973_Br.J.Pharmacol_49_557 |
PubMedID: 4777716 |
Brezenoff HE (1973)
The role of brain acetylcholine in the pressor response to centrally infected neostigmine
British Journal of Pharmacology
49 :557
Brezenoff HE (1973)
British Journal of Pharmacology
49 :557