Brezenoff_1988_Pharmacology_36_101

Reference

Title : Blockade of brain M2 muscarinic receptors lowers blood pressure in spontaneously hypertensive rats - Brezenoff_1988_Pharmacology_36_101
Author(s) : Brezenoff HE , Vargas H , Xiao YF
Ref : Pharmacology , 36 :101 , 1988
Abstract :

Injections of the M2 muscarinic receptor antagonist 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP; 1.5-40 micrograms) into the cerebral ventricles of urethane-anesthetized rats caused a dose-related inhibition of the pressor response to intravenously injected physostigmine. A similar reduction was obtained with 1/80th the dose of methylatropine, but not with the selective M1 antagonist pirenzepine. Intraventricular injection of 4-DAMP (6.25-25 micrograms) caused a dose-related reduction in blood pressure in unanesthetized spontaneously hypertensive rats (SHR), but not in normotensive controls. Systolic pressure fell 42 +/- 6 mm Hg at the 25-micrograms dose. Pirenzepine did not lower blood pressure in SHR and inhibited the antihypertensive effect of 4-DAMP.

PubMedSearch : Brezenoff_1988_Pharmacology_36_101
PubMedID: 3353437

Related information

Citations formats

Brezenoff HE, Vargas H, Xiao YF (1988)
Blockade of brain M2 muscarinic receptors lowers blood pressure in spontaneously hypertensive rats
Pharmacology 36 :101

Brezenoff HE, Vargas H, Xiao YF (1988)
Pharmacology 36 :101