Title : Blockade of brain M2 muscarinic receptors lowers blood pressure in spontaneously hypertensive rats - Brezenoff_1988_Pharmacology_36_101 |
Author(s) : Brezenoff HE , Vargas H , Xiao YF |
Ref : Pharmacology , 36 :101 , 1988 |
Abstract :
Injections of the M2 muscarinic receptor antagonist 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP; 1.5-40 micrograms) into the cerebral ventricles of urethane-anesthetized rats caused a dose-related inhibition of the pressor response to intravenously injected physostigmine. A similar reduction was obtained with 1/80th the dose of methylatropine, but not with the selective M1 antagonist pirenzepine. Intraventricular injection of 4-DAMP (6.25-25 micrograms) caused a dose-related reduction in blood pressure in unanesthetized spontaneously hypertensive rats (SHR), but not in normotensive controls. Systolic pressure fell 42 +/- 6 mm Hg at the 25-micrograms dose. Pirenzepine did not lower blood pressure in SHR and inhibited the antihypertensive effect of 4-DAMP. |
PubMedSearch : Brezenoff_1988_Pharmacology_36_101 |
PubMedID: 3353437 |
Brezenoff HE, Vargas H, Xiao YF (1988)
Blockade of brain M2 muscarinic receptors lowers blood pressure in spontaneously hypertensive rats
Pharmacology
36 :101
Brezenoff HE, Vargas H, Xiao YF (1988)
Pharmacology
36 :101