Title : Carbofuran in water: Subchronic toxicity to rats - Brkic_2008_Environ.Toxicol.Pharmacol_25_334
Author(s) : Brkic DV , Vitorovic SL , Gasic SM , Neskovic NK
Ref : Environ Toxicol Pharmacol , 25 :334 , 2008
Abstract :

Carbofuran toxicity on rats was studied during subchronic exposure. Female and male rats were administered carbofuran in drinking water in concentrations of 25, 100 and 400ppm for a period of 90 days. Clinical symptoms, water consumption, body weight gain, organ weight, pathological and histopathological changes in the liver and kidneys were observed and biochemical and haematological examinations were carried out. The results obtained show that carbofuran administered to rats caused a significant decrease in water consumption as well as in brain, serum and erythrocyte cholinesterase activities. Statistically significant increases in relation to the control were found in the serum enzyme activities. The haematological data showed that carbofuran had no significant effect on Hb concentration and total RBC, but total WBC showed a significant statistical decrease. The histopathological changes in liver and kidneys were observed. However, cell regeneration in the liver and kidneys was found in all test groups.

PubMedSearch : Brkic_2008_Environ.Toxicol.Pharmacol_25_334
PubMedID: 21783871

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Citations formats

Brkic DV, Vitorovic SL, Gasic SM, Neskovic NK (2008)
Carbofuran in water: Subchronic toxicity to rats
Environ Toxicol Pharmacol 25 :334

Brkic DV, Vitorovic SL, Gasic SM, Neskovic NK (2008)
Environ Toxicol Pharmacol 25 :334