| Title : Enantioselective total synthesis and biological evaluation of (-)-solanacol - Bromhead_2018_Org.Biomol.Chem_16_5500 |
| Author(s) : Bromhead LJ , Norman AR , Snowden KC , Janssen BJ , McErlean CSP |
| Ref : Org Biomol Chem , 16 :5500 , 2018 |
|
Abstract :
An enantioselective synthesis of the phenyl ring-containing strioglactone, (-)-solanocol, is described. Application of a Dynamic Kinetic Resolution (DKR) in the stereo-defining step enabled a step-economical synthesis to be achieved, and allowed access to natural and non-natural enantiomers with equal facility. Results of seed germination assays and Differential Scanning Fluorimetry (DSF) measurements with the known strigolactone receptor protein, Decreased Apical Dominance 2 (DAD2), are reported. |
| PubMedSearch : Bromhead_2018_Org.Biomol.Chem_16_5500 |
| PubMedID: 30027185 |
| Inhibitor | Solanacol |
Bromhead LJ, Norman AR, Snowden KC, Janssen BJ, McErlean CSP (2018)
Enantioselective total synthesis and biological evaluation of (-)-solanacol
Org Biomol Chem
16 :5500
Bromhead LJ, Norman AR, Snowden KC, Janssen BJ, McErlean CSP (2018)
Org Biomol Chem
16 :5500