| Title : A long-lasting cholinesterase inhibitor affecting neural and behavioral processes - Brufani_1987_Pharmacol.Biochem.Behav_26_625 |
| Author(s) : Brufani M , Castellano C , Marta M , Oliverio A , Pagella PG , Pavone F , Pomponi M , Rugarli PL |
| Ref : Pharmacol Biochem Behav , 26 :625 , 1987 |
|
Abstract :
A series of analogues of physostigmine were prepared with the aim of investigating their inhibitory effects on acetylcholinesterase in the treatment of Alzheimer's disease. One of the isomers prepared was evaluated for its anticholinesterase activity in vivo, acute toxicity, and some behavioral effects. This compound was a competitive inhibitor of the enzyme and was found to antagonize the stimulating effect produced by scopolamine on locomotor activity and to facilitate memory consolidation. |
| PubMedSearch : Brufani_1987_Pharmacol.Biochem.Behav_26_625 |
| PubMedID: 3575379 |
Brufani M, Castellano C, Marta M, Oliverio A, Pagella PG, Pavone F, Pomponi M, Rugarli PL (1987)
A long-lasting cholinesterase inhibitor affecting neural and behavioral processes
Pharmacol Biochem Behav
26 :625
Brufani M, Castellano C, Marta M, Oliverio A, Pagella PG, Pavone F, Pomponi M, Rugarli PL (1987)
Pharmacol Biochem Behav
26 :625