| Title : Synthesis of 2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan: a new analogue of heptylphysostigmine (MF 201) - Brufani_1994_Farmaco_40_743 |
| Author(s) : Brufani M , Filocamo L , Imbriani E , Lappa S , Mannina L |
| Ref : Farmaco , 40 :743 , 1994 |
|
Abstract :
The synthesis of 2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan is described. The compound is structurally related to the cholinesterase inhibitor heptylphysostigmine (MF 201) because the angular methyl group of the esoroline nucleus has been changed into a bridging carbon and the anilinic nitrogen has been replaced by a methylene group. This compound proved to be a potent cholinesterase in vitro inhibitor. |
| PubMedSearch : Brufani_1994_Farmaco_40_743 |
| PubMedID: 7832976 |
| Inhibitor | Heptylphysostigmine |
Brufani M, Filocamo L, Imbriani E, Lappa S, Mannina L (1994)
Synthesis of 2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan: a new analogue of heptylphysostigmine (MF 201)
Farmaco
40 :743
Brufani M, Filocamo L, Imbriani E, Lappa S, Mannina L (1994)
Farmaco
40 :743